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The overall incidence of reported adverse reactions of hypoglycemia in patients with type 2 diabetes inadequately controlled on diet and exercise was 0.6% in patients given placebo, 0.6% in patients given sitagliptin alone, 0.8% in patients given metformin immediate-release alone, and 1.6% in patients given sitagliptin in combination with metformin immediate-release

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Gastrointestinal and Sleep Research Studies on gastrointestinal motility have revealed that Ipamorelin can stimulate gastric emptying and intestinal transit, which has led to research exploring its potential for post-surgical ileus and gastroparesis