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As expected, whole-cell patch-clamp electrophysiological recordings showed that PVN Glu neuronal activity was significantly higher in the AAV-DIO-shMOR-EGFP group than that in AAV-DIO-EGFP-expressing controls (Fig

Cav-1 has also been proved to modulate vascular tone in animal models

NAD-boosting increased 4-6 fold the blood NAD + depending on individual, pointing to need of personalized dose adjustment in treatment trials