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Cocaine binds to the norepinephrine transporter (NET) and other closely related monoamine transporters (DAT & SERT) at a common core area known as the central substrate-binding site, also referred to as the S1 pocket (Acharya Dahal et al., 2014

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While many of these mechanisms are still unknown, there is growing evidence that ferroptosis plays a key role in obesity and its complications, including type II diabetes, hypertension, nonalcoholic steatohepatitis, atherosclerosis, and obese cardiomyopathy (171)

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Targeting DAMPs with nucleic acid scavengers to treat lupus