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However, challenges such as gastrointestinal side effects and high medication costs are limiting broader accessibility

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doi: 10.1016/j.atherosclerosis.2011.12.039

One in five adults has taken a GLP-1 drug at some point, according to a November 2025 poll from health-care think tank KFF

For broader questions about how safe these medications are in general, the SELECT trial data, and what the 2024 to 2026 evidence shows on the most-discussed concerns, see our separate guide on whether weight-loss injections are safe

Appetite changes and mild stomach symptoms are common