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This dual effect could explain why GLP-1 analogues, unlike dexamethasone, improve both synovitis and fibrosis in preclinical models

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Over time, metformins ability to treat insulin resistance without weight gain or increased risk of hypoglycemia was recognized, and it was introduced to the US in 1995

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Effectively managing weight is a clinical necessity to lower blood pressure and dampen the inflammatory cytokines that destroy renal architecture over time