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Both the GLP-1R/GIP coagonist and the tri-agonist similarly reduced blood glucose levels and improved glucose tolerance without induction of hypoglycaemia, and this demonstrates that chronic GCGR agonism does not overpower the anti-hyperglycemic effects of GLP-1R and GIPR activation

Clinical data shows an average regain of 5070% of lost weight within 12 months after discontinuation, though individual results vary significantly

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