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The accumulated ROS in cells interacts with Ca 2+ , increasing the permeability of the endoplasmic reticulum membrane by promoting redox modification of Ca 2+ channels, leading to the release of Ca 2+ reserves from the endoplasmic reticulum into the cytoplasm and inducing Ca 2+ overload (91)

Additionally, H&E staining (Fig

Carnitine administration enhanced glycogen storage and glucose oxidation in T2DM patients (Vidal-Casariego et al., 2013)

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Therefore, effective strategies to manage T2DM should not only address hyperglycaemia but also prevent further progression of the disease and its associated complications

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