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If you had to do hours of manual labor, or you had to hunt for your food and chase it in order to have an adequate number of calories

Lanzone, Role of Opioid Antagonists in the Treatment of Women with Glucoregulation Abnormalities, Current Pharmaceutical Design, vol

This captures fat loss that the scale might miss during periods of water retention

2020;11:e00178

Studies in mice with CNS neuron-specific GLP-1R knockout showed that liraglutide failed to induce weight loss but still improved glucose levels, suggesting that brain GLP-1Rs are necessary for the weight-lowering effect of GLP-1RAs but not essential for their glucose-lowering effects (142)

Below, a snapshot of what an integrative approach to GLP-1s can look like