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The tDCS upregulates monocarboxylate transporter 1 (MCT1) expression and propionate (PPA) level, reduces phosphorylation and activity of phosphatase and tensin homolog (PTEN) in neurons, and thereby alleviates PTEN-mediated transcriptional repression of LONP1, ultimately enhancing LONP1-dependent mitochondrial protection

Loguercio, C., et al

These facts have an important impact on the interpretation of the results

Orforglipron is a daily pill just approved as Foundayo from Eli Lilly that works similarly to GLP-1 medications

Instead, it is a combination of diet and environment, which interacts with increased susceptibility due to the MTHFR variants

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