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Male patients commonly lose 12 pounds per week during the first 8 weeks, with cumulative weight loss averaging 1522% of baseline body weight by week 68 of treatment

Patients seeking moderate weight loss (10-15% body weight): Orforglipron's Phase 3 data show mean weight loss of approximately 11% at 72 weeks, with about 55% of participants achieving 10% or greater loss

External eating refers to eating behavior triggered by external cues such as appetizing smells, the visual appeal of food, or observing others eat

This will make it easier to take specific doses, and may be easier to consume for some

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The biggest takeaway from clinical trials is that side effects are dose-related and almost always show up during dose increases