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PMID 8017933

Following this, the SURPASS-3 trial evaluated tirzepatide in patients with T2DM inadequately controlled by metformin, with or without SGLT2 inhibitors

The S-acetyl modification serves two purposes: it makes the molecule more stable and resistant to degradation in the GI tract, and it may help the molecule cross cell membranes more easily than unmodified reduced glutathione