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Use twice daily for best results, with sunscreen during the day

Monitor and Adjust Therapy Regular follow-up is essential when starting or adjusting GLP-1 therapy

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Levodopa and cobalamin-related neurotoxic metabolites and benefits of COMT inhibitors The breakdown of LDopa through COMT requires methyl group transfer, leading to the formation of the stable compound 3-O-MethylDopa (Mller and Riederer 2023)