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Impact of concomitant thiopurine on the efficacy and safety of filgotinib in patients with ulcerative colitis: post hoc analysis of the phase 2b/3 selection study

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This effect may be due either to inhibition of carbamyl phosphate synthase (CPS) I by -oxidation metabolites (CPS I is the first mitochondrial enzymatic step of the urea cycle) or to decreased synthesis of N -acetyl glutamic acid (NAGA) from acetyl-CoA and glutamate by NAGA synthetase (NAGA is an important cofactor of CPS I)

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8 , 330ra337 (2016)