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HRW upregulates antioxidant enzymes (HO-1, SOD-1) while suppressing pro-inflammatory cytokines (IL-1, IL-6, TNF-) and NF-B activation (38)

In case of the transporter-mediated prodrug approach, the rational design of prodrugs should take into account the functional expression and structural requirements for substrate binding and translocation via the transporter, as well as capability to be bioconverted by an enzyme at the target site (74)

In a study, it was reported that the SOD level decreased significantly in patients with migraine 17

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This blocks pigment production and makes the hair turn white