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PMID: 22500213 Meister, A

While these average changes seem minimal, caution is warranted: if a patient has underlying high blood pressure or heart disease, even transient increases could be risky

Park et al., 2019

Firstly, it uses about 20% of the bodys oxygen supply for energy production (and energy production is a significant source of reactive oxygen species (ROS)

[2] This is the highest tier of evidence in this entire comparison: randomized, blinded, placebo-controlled, with a hard imaging endpoint (visceral fat measured by CT), replicated across two trials, and reviewed by a regulator

11 The nonpeptide GLP-1 RA orforglipron (Foundayo) was approved in April 2026, becoming the second oral IBT available for chronic weight management