H., Karki, K., Cheng, Y., Michelhaugh, S
M2 macrophages are more susceptible to ferroptosis than M1 macrophages, and this susceptibility is associated with the Extracellular signal-regulated kinase (ERK)-Cytosolic phospholipase A2 (cPLA2)-ACSL4-mediated activation of the arachidonic acid metabolic pathway [63]
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ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury
It protects your cells from oxidative damage, supports detoxification, and plays a major role in immune defense