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This is particularly crucial for breaking the estrogen-histamine loop

Because Se interferes with S metabolism and can replace S in the S-amino acids which results into the production of the corresponding Se-amino acids (seleno-Cys and selenomethionine), their subsequent incorporation into enzymatic proteins may affect catalytic activity (Ellis and Salt, 2009)

Trends Microbiol 12(9): 417-423

An imbalance of glutathione is present in many pathologies including cancer, neurodegenerative disorders, cystic fibrosis (CF), HIV and aging