Persistent post-bariatric-surgery hypoglycemia: a long-term follow-up reassessment
Together with our GLP-1 Companion Program, these tools help deliver powerful results, not just in near-term weight loss but in creating lasting habits that truly make a difference in long-term health." About Noom: Noom is a digital healthcare company empowering everyone, everywhere to live better longer, through an unwavering commitment to innovation and whole-person health
If youre a clinician considering microdosing: Be explicit: We dont know exactly how or why this might work at this dose Consider it especially for: Normal-weight patients with metabolic dysfunction Patients who cant tolerate higher doses Conditions with strong mechanistic rationale (PCOS, autoimmune disease, addiction) Monitor objectively: weight and body composition, waist circumference, labs, symptom scores, not just subjective reports Track patients who dont lose weight but report benefits - these are your most interesting cases Document everything, contribute to registries If youre a patient considering microdosing: Understand that benefits without weight loss are reported but not proven Know that you might be benefiting from small amounts of visceral fat loss that dont show on your scale Be skeptical of your own subjective improvement (placebo is real) Know that all medications come with possible side effects Work with a clinician who will help you figure out if its actually working If youre a researcher: Please study the minimal effective dose Use imaging to measure visceral fat, not just scale weight Design studies in normal-weight metabolically unhealthy individuals Compare weight-matched groups to isolate non-weight-loss effects My opinion
Wegovy mimics a single hunger hormone called GLP-1, whilst Mounjaro mimics two hormones: GLP-1 and GIP
Oxyntomodulin, produced by the L-cells in the distal small intestine, binds to both glucagon receptor and GLP-1 receptor and is structurally very similar to glucagon
Over the following decade, rapid advances in molecular biology expanded this framework
