In a patient who has completed treatment for thyroid cancer and is euthyroid on stable levothyroxine, can oral GLP1 receptor agonists (e.g., oral semaglutide, orforglipron) be used for weight loss, and are phentermine or other oral weightloss agents appropriate?
A landmark 2023 JAMA study found GLP-1 users face significantly elevated risks: 3.67 times higher risk of gastroparesis, 4.22 times higher risk of bowel obstruction, and 9.09 times higher risk of pancreatitis compared to patients using other weight loss medications
Anam M, Maharjan S, Amjad Z, Abaza A, Vasavada AM, Sadhu A, Valencia C, Fatima H, Nwankwo I (2022) Efficacy of semaglutide in treating obesity: a systematic review of randomized controlled trials (RCTs)
Your pharmacy will likely carry at least one of these, and can dispense one if you have a prescription
Recognizing a plateau early matters because the longer you wait, the more frustration builds and the harder it becomes to identify what actually needs adjustment
So GLP-1 medications, it seems, help shift the immune system toward a more tolerant, less Im a feral child state