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Once inside the brain, pyridostigmine directly enhances neuronal excitability and induces an early transcriptional response that increases c-fos and AChE mRNAs (Friedman et al, 1996)

doi: 10.1186/s13075-020-02348-z 78 HaraguchiM.KimY.WatanabeN.YamazakiK.NewmanK

Some medications are designed so that the metabolite the substance created after phase I metabolism is actually the active drug

Turchi R, Faraonio R, Lettieri-Barbato D, Aquilano K

Kojic Acid: A revered skin-lightening agent, kojic acid works diligently to reduce the appearance of dark spots, hyperpigmentation, and melasma, unveiling a more even and radiant skin tone

This suggests that low glutamine promotes CAF migration and invasion, which in turn facilitates tumor cell movement towards nutrient-rich areas (132)