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High-throughput screening campaigns against the GLP-1 receptor and other class B GPCRs consistently yielded low hit rates for small molecules, and the few hits that emerged typically showed micromolar potency, insufficient for therapeutic applications

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In clinical trials, people taking Contrave lost an average of about 8% of their initial body weight after 56 weeks, compared to less than 2% in those who took a placebo (inactive medicine)

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