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In the late stage, complications, such as upper gastrointestinal bleeding, hepatic encephalopathy, secondary infection, hypersplenism, ascites, and cancer are common ( in vivo studies have also found that caffeine inhibited the activation of hepatic stellate and sinusoidal endothelial cells, which was reversed by CPA (1 mg/kg/day, i.p.) and GCS21680 (0.5 mg/kg/day, i.p.) (Figure 3) ( 2.5 Caffeine in (autoimmune) hepatitis Hepatitis is a general term for liver inflammation, which usually refers to liver cells destroyed by various pathogenic factors, such as viruses, bacteria, parasites, chemicals, poisons, drugs, alcohol, and autoimmune factors

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I.KutlarA.KanterJ.LilesD.CancadoR.FriedrischJ.et al (2017)