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Overall agreement 80%: A+ 55%, A 25%, A 20%, D 0%, D 0%, D+ 0%

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MOH could be stratified into simple and complex phenotypes according to different clinical parameters (i.e., amounts and class of analgesics, psychiatric comorbidities, history of relapse after withdrawal, symptoms of central sensitization and maladaptive anticipatory response to pain experience)

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A: Dose 1-2 hours before your largest or highest-calorie meal of the day