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Vegetarians and vegans may need to take an over-the-counter B12 supplement to ensure they're getting enough, but people with vitamin B12 absorption issues may require prescription B12 injections

The biggest downside is cost

As first described back in the 1950s, about one in ten people erupted in acne within days or even hours of getting an injection of vitamin B12, but it disappeared rapidly when the B12 shots stopped

specifically, semaglutide is a GLP-1 receptor agonist with 94% sequence homology to human GLP-1

This minimum requirement becomes the de facto standard

Hormonal changes extend beyond metabolic hormones