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Methylenetetrahydrofolate reductase: biochemical characterization and medical significance

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Thus, diabetic cholesterol dyshomeostasisinner BRB leak plus reduced conversion to soluble oxysterols by RPE and neuroretinaelevates retinal cholesterol and drives DR (4852)

These studies generally demonstrate favorable safety profiles, although their therapeutic efficacy is often limited by poor aqueous solubility, rapid metabolism, and low systemic bioavailability