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The Saxagliptin Assessment of Vascular Outcomes (SAVOR-TIMI 53) study is a similar study in 12,000 patients comparing saxagliptin with placebo in diabetic patients with high cardiovascular risk

There is a genuine biological mechanism at work

Clinical trials have reported decreases in high-sensitivity C-reactive protein (hs-CRP), a well-established biomarker of systemic inflammation and cardiovascular risk

It also controls appetite by regulating stomach emptying and our subjective experience of fullness via the brain

Cortisol directly impairs insulin signaling pathways that overlap with GLP-1 receptor cascades

Differentiating between cardiac chest pain and other causes in patients taking tirzepatide requires careful clinical assessment