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13 The absence of Tyr 1 from the N-terminal of GIP dramatically decreases its activity

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The gastrointestinal side-effect profile of retatrutide observed in phase 2 trials is broadly consistent with other GLP-1-based therapies, such as semaglutide (Wegovy/Ozempic) and tirzepatide (Mounjaro), though retatrutide's additional glucagon receptor activity means its full profile may differ in ways that phase 3 data will clarify

Potential BenefitsCompounded pharmacy equivalent to Zepbound / Mounjaro (tirzepatide)Proven GIP and GLP-1 therapy with years of clinical research Needle-free, discreet ODT format