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However, long-term administration of GCs at high doses is frequently associated with severe adverse effects, in particular, metabolic disorders and atrophic effects, including musculoskeletal side effects (glucocorticoid-induced osteoporosis (GIO), osteonecrosis, myopathy), disorders of carbohydrate and fat metabolism (diabetes mellitus, dyslipidemia, obesity), gastrointestinal, cardiovascular effects (Fig

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