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DHA at concentrations 20 mM did not impair viability, whereas higher doses (40 mM) led to significant cell death

Solubility: Fully soluble in water (HO) and acetic acid solutions

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Thus, sustained PERK pathway activation integrates proteostasis control with angiogenic and invasive programs, positioning this UPR branch as a central driver of tumor progression rather than a mere stress-response mechanism