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Published December 29, 2022

Be Cautious With Effective at a Lower Dose A formulation may produce higher blood exposure in a pharmacokinetic study, but that does not automatically establish that a lower dose produces the same clinical result

DHODH activity is essential for proliferating cells owing to their increased demand for nucleotides, and DHODH inhibition has long been studied as a therapeutic strategy in autoimmune diseases (for example, via leflunomide) and cancer, where it can lead to cell cycle arrest, DNA damage and replication stress 42,44,45

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