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*Correspondence: Helton Estrela Ramos, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Thyroid Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The blood-brain barrier is important because it directly pumps these drugs from the brain into the hypophyseal circulation, which supplies the pituitary