Analyzing obesity classification based on body mass index (BMI), the researchers found that compared to overweight patients (BMI between 25 and 29.9), the chances of GLP-1 use were 1.73 times higher among class 1 obesity patients (BMI between 30 and 34.9), 2.19 times higher among class 2 obesity patients (BMI between 35 and 39.9), and 2.69 times higher among patients with class 3 obesity (BMI 40 or higher)-the most severe form
Despite the use of these drugs, there was no increased incidence of congenital malformations in this cohort as compared to those on insulin
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No patient developed lactic acidosis during a follow up period of 26.8 months.37 Although these studies did not report the glycemic effects, it is likely that better glycemic control was a contributor to reduced morbidity and mortality
Increased insulin secretion during a fasting state was also observed for other long-acting GLP-1 RAs such as dulaglutide (Trulicity) [110] and albiglutide (Tanzeum) [111]
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