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The effects of smoking are well-established and contradictorysignificantly increasing the risk of CD, disease activity, and the need for surgery/hospitalization [173, 278], However, smoking demonstrates a protective effect in UC [173, 279], and the risk of relapse in UC increases immediately after smoking cessation [280, 281], It may also amplify the effects of certain genetic variations through gene-environment interactions [282]
However, none of the studies reported on hematological or clinical outcomes
Lowering adenosine levels with PEGylated adenosine deaminase has been shown to enhance CD8 + T cell activation and improve the response to immune checkpoint inhibitor therapy [44]
Anisimov VN, Khavinson VK, Morozov VG
A severe case can cause rapid weight loss and nutritional deficiencies
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