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Journal of cardiovascular pharmacology, 82(2), 8692
The peptide upregulates matrix metalloproteinase (MMP) production, facilitating basement membrane degradation necessary for cellular movement and a comprehensive review in Frontiers in Endocrinology has detailed how its actin-binding properties regulate cytoskeletal function across multiple tissue repair contexts
These limitations have driven decades of research into smaller molecules that can activate TrkB signaling with better pharmacokinetic properties
I., Tsilimigras, D
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