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Dual GIP and GLP-1 receptor agonist GLP2 improves beta-cell function and insulin sensitivity in type 2 diabetes

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Salen ligands contain N2O2 donor sites and may offer metal ions to adopt square planar (4-coordinate), square pyramidal (5-coordinate), or octahedral (6-coordinate) environments

Mouse islets were subsequently washed, purified using a Histopaque gradient (Histopaque-1119 and Histopaque-1083, SigmaAldrich) and rested overnight at 37 C in a 95% O 2 /5% CO 2 incubator before performing experiments in mouse islet culture medium (RPMI-1640 with 11 mM D-glucose, supplemented with 10% FBS and 1% penicillin/streptomycin)

While WeGovy is also approved by the FDA to treat obesity, other similar drugs are increasingly being prescribed off-label for weight loss

doi:10.1002/oby.24067 CDC