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[4] [5] Biological function [edit] Lipoic acid is a cofactor for five enzymes or classes of enzymes: pyruvate dehydrogenase, -ketoglutarate dehydrogenase, the glycine cleavage system, branched-chain alpha-keto acid dehydrogenase, and the -oxo(keto)adipate dehydrogenase

Among the five removed from Category 2 in September 2024 and now under PCAC review

Certain individuals should seek alternatives

Ozempic contains semaglutide at doses up to 1mg and is licensed for type 2 diabetes

Patients should also seek medical advice for progressive or persistent vision changes that develop after starting Zepbound

Indeed, unlike other thiols, homocysteine incubation with endothelial cells induces an increased expression of the stress protein GRP78 and a decreased expression of glutathione peroxidase, a major intracellular antioxidant enzyme, through a mechanism that depends on an alteration of the intracellular redox potential (Kokame et al, 1996