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Given the early stages of this therapeutic approach senescence therapeutics will need to overcome challenges related to biomarker identification, target engagement, CNS penetrance and safety

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This creates permanent improved blood supply

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Collectively, our findings demonstrate that the GPX4 inhibition by RSL3 in PTC cells induces cell death, ferroptosis, lipid peroxidation, increased intracellular ROS burden, and significantly impairs thyroid tumor cell migration, 3D PTC spheroid fotmation and results in reduced spheroid viability in vitro