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PARP-1 selectively impairs KRAS-driven phenotypic and molecular features in intrahepatic cholangiocarcinoma

Jiang LY, Zhang XL, Du P, Zheng JH

In patients with acute type A aortic dissection, CD4 + T cells exhibit a hypofunctional phenotype associated with poor clinical outcomes

The sensor is part of a protein that does triple duty: it senses, regulates, and delivers the antioxidant glutathione into the mitochondrial interior, where it plays critical roles in tamping down oxidizing reactions and maintaining appropriate iron levels

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