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Effect of DPP-4 inhibitors on microvascular events in landmark trials An adequate assessment of the effect of antidiabetic drugs on the risk of microvascular events requires trials that evaluate durations of glucose-lowering treatments administered for a decade or longer

Another reading suggests that broad gene-expression effects can reflect secondary consequences (changes in cell state, in proliferation rate, in metabolism) rather than direct mechanism-based effects, and that the specificity of the transcriptomic findings should be interpreted with caution

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Competitive Landscape Orforglipron will enter a rapidly evolving competitive landscape for obesity and diabetes treatment