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Researchers have suggested that these benefits may be due to the effects of epithalon on reducing the expression of the apoptosis-inducing caspase-3 and consequently MMP-9 (matrix metalloproteinase-9) in aged skin fibroblast cultures

19,88 (iv) Markers of astrocyte reactivity

As we mentioned above, methionine and cysteine are susceptible to oxidation, forming methionine sulfoxide, cysteineglutathione disulfide, and cysteine sulfinic acid, all of which were higher in fibroblasts undergoing replicative senescence than in controls (Quijano et al., 2012

Immunohistochemistry staining Animal Research Kit (ARKTM) was used to detect the immunohistochemical localization proteins of HSP70 (1:100) and Bax (1: 200) on the study slides

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