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A 2025 meta-analysis of 16 studies involving 6,098 participants found no statistically significant difference between intramuscular, oral, and sublingual B12 supplementation routes (p=0.270)
doi: 10.33549/physiolres 21 BollePEvandriMGSasoL
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The study concludes that DSIPs activating action on oxidative phosphorylation and its preventive effects under hypoxia provide a strong basis for understanding its previously reported stress-protective and antioxidant actions in vivo
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