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VEGF stands as a pivotal driver behind the genesis of fresh blood vessels through both vasculogenesis and angiogenesis, exerting a profound influence on endothelial proliferation (McConnell et al

The link between this principle and autoimmune diseases was then shown in the 1980s, when Imbach and colleagues found that injection of a large pool of exogenous IgG (IVIg) alleviated idiopathic thrombocytopenia (ITP) [94,95,96]

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