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The newer cholesterol-lowering medications, PCSK9 inhibitors, have been shown to lower Lp(a) levels.[ref] A 2026 placebo-controlled clinical trial using the PCSK9 inhibitor enlicitide also showed a decreased in Lp(a) levels at 24 weeks.[ref] Aspirin: A study of over 12,000 people over age 70 looked at the effect of 100mg of aspirin daily
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Animal-model evidence consistently shows local effects: angiogenesis at the injury site (VEGF upregulation), growth-factor signaling (EGF, FGF), nitric oxide pathway modulation, and accelerated tendon-to-bone interface healing in rat Achilles transection studies
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