In combination research protocols, published models have explored GHRH analogues paired with ipamorelin exploiting a synergistic mechanism whereby GHRH receptor activation and GHS-R1a activation cooperate to amplify GH pulse amplitude beyond either compound alone
Acknowledgements The authors receive funding support from the Cancer Prevention and Research Institute of Texas (grant RP190570 to L.H.) and National Institutes of Health (grants R01HL141466, R01HL155990 and R01HL156021 to J.J.M.)
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