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Multiple Phase 3 TRIUMPH trials are expected to report results this year

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Most patients report improvements in skin texture, firmness, and hydration within 4-8 weeks

This "Triple Threat" approach is often compared to a "push-pull" system: The Push (GLP-1/GIP): Pushing energy intake down through satiety and appetite suppression

PMID: 1511571 58

Indeed, there exist limited studies directly evaluating the effect of GLP-1RAs on central pain, but modulation of the central pain pathways by GLP-1-RA-based therapies has been proposed in patient groups suffering from fibromyalgia and chronic lower back pain [100]