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Methods: A systematic literature review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines

"The best outcomes come from correctly identifying the underlying problem and tailoring the treatment accordingly rather than simply responding to the latest trend." With a solid foundation in place, surgeons say the wisest approach is to begin with smaller treatments and escalate only if needed

Lenzi A, Sgr P, Salacone P, Paoli D, Gilio B, Lombardo F, et al

Tissue-specific expression of the calcitonin gene is regulated by two widely separated enhancer regions

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Current DAMP/PRR-targeted therapeutic strategies are comprehensively reviewed, including: modulating cell death pathways to reduce DAMP release, neutralizing DAMP activity using monoclonal antibodies, developing small-molecule inhibitors to block signaling pathways, and employing enzymatic degradation or gene silencing technologies for precise intervention