The analysis showed significantly greater WL in the GLP-1RAs group compared to placebo (SMD = 0.82, 95% CI 0.23 to 1.42)
Four key genetic variantsGIPR rs1800437, GLP1R rs6923761, FTO rs9939609, and MC4R rs17782313significantly influence appetite regulation, fat storage, and metabolic rate
Cell (2004) 118(2):22941.10.1016/j.cell.2004.07.002 146 WorthingtonJJSamuelsonLCGrencisRKMcLaughlinJT
However, liver-related outcomes and deaths did not differ based on IgG levels (log-rank p=0.93)
Prospective trials are needed to further define potential protective effects of these medications in glaucoma and AMD
The Revised International Association for the Study of Pain Definition of Pain: Concepts, Challenges, and Compromises