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Increased incidence or severity of renal pelvic dilatation was observed in 21-day-old pups offspring of treated dams at 75 mg/kg/day (maternal and pup dapagliflozin exposures were 1415-times and 137-times, respectively, the human values at the 10 mg clinical dose, based on AUC)

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Also, several studies have shown that the activation of STING contributes to pyroptosis via the TBK1-IRF3 signal (138, 139)