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Also, a shrunken nuclear membrane and increased heterochromatin, with marked loss of the rough endoplasmic reticulum and disrupted mitochondria, were observed in the electron micrographs

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J Biol Chem 257(8):42484252 Bautista AP, Mszros K, Bojta J, Spitzer JJ (1990) Superoxide anion generation in the liver during the early stage of endotoxemia in rats