As shown in Figure 2, when an intracellular iron overload occurs, excess iron promotes lipid peroxidation through ROS production and Fenton reaction, thus causing ferroptosis ( TFRC gene encoding TRF1 inhibits erastin-induced ferroptosis and prevents LIP accumulation, while HO-1 promotes ferroptosis by supplementing iron ( TRFC , FTH1 , and FTL (Sun et al., 2015)
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Water-soluble vitamins in cells and spent culture supernatants of Poteriochromonas stipitata, Euglena gracilis, and Tetrahymena thermophila
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